Population pharmacokinetics and exploratory pharmacodynamics of ifosfamide according to continuous or short infusion schedules: an n = 1 randomized study

AIMS: To model the pharmacokinetics and pharmacodynamics of ifosfamide and its key metabolites. The pharmacodynamic parameters included were renal toxicity and myelosuppression measured using urinary β(2)-microglobulin (BMG) and absolute neutrophil count (ANC), respectively. METHODS: Seventeen patie...

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Hauptverfasser: Brain, Etienne G C, Rezai, Kevan, Lokiec, François, Gutierrez, Maya, Urien, Saïk
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2008
Schlagworte:
Short Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291389/
https://ncbi.nlm.nih.gov/pubmed/18294323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.03095.x
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