Interindividual variability in the concentration–effect relationship of antilymphocyte globulins—a possible influence of FcγRIIIa genetic polymorphism

AIMS: Polyclonal antilymphocyte globulins (ALGs) are currently used in transplantation, but the sources of interindividual variability of their effect are poorly understood. No pharmacokinetic–pharmacodynamic (PK–PD) study of ALG is available. Moreover, the genetic polymorphism of FcγRIIIa, a recept...

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Hlavní autoři: Ternant, David, Büchler, Matthias, Bénéton, Maud, Alván, Gunnar, Ohresser, Marc, Touchard, Guy, de Ligny, Bruno Hurault, Toupance, Olivier, Watier, Hervé, Lebranchu, Yvon, Paintaud, Gilles
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2008
Témata:
Pharmacogenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291273/
https://ncbi.nlm.nih.gov/pubmed/17610526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.02967.x
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