Interindividual variability in the concentration–effect relationship of antilymphocyte globulins—a possible influence of FcγRIIIa genetic polymorphism

AIMS: Polyclonal antilymphocyte globulins (ALGs) are currently used in transplantation, but the sources of interindividual variability of their effect are poorly understood. No pharmacokinetic–pharmacodynamic (PK–PD) study of ALG is available. Moreover, the genetic polymorphism of FcγRIIIa, a recept...

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Detalles Bibliográficos
Autores principales: Ternant, David, Büchler, Matthias, Bénéton, Maud, Alván, Gunnar, Ohresser, Marc, Touchard, Guy, de Ligny, Bruno Hurault, Toupance, Olivier, Watier, Hervé, Lebranchu, Yvon, Paintaud, Gilles
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2008
Materias:
Pharmacogenetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291273/
https://ncbi.nlm.nih.gov/pubmed/17610526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.02967.x
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