Time-dependent inhibition of human drug metabolizing cytochromes P450 by tricyclic antidepressants

AIMS: To investigate time-dependent inhibition (TDI) of human drug metabolizing CYP enzymes by tricyclic antidepressants (TCAs). METHODS: CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A/CYP3A4 activities were investigated following co- and preincubation with TCAs using human liver microsomes (HLM) and hum...

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Bibliographic Details
Main Authors: Polasek, Thomas M, Miners, John O
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2008
Subjects:
Drug Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291266/
https://ncbi.nlm.nih.gov/pubmed/17662092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.02964.x
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