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Population pharmacokinetics of gemcitabine and its metabolite in patients with cancer: effect of oxaliplatin and infusion rate

AIMS: To characterize the population pharmacokinetics of gemcitabine and its metabolite (dFdU) in patients with cancer and identify factors that are influential in gemcitabine dose regimen design. METHODS: Gemcitabine and dFdU plasma concentration–time and clinical data from 94 patients with cancer...

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Autori principali: Jiang, Xuemin, Galettis, Peter, Links, Matthew, Mitchell, Paul L, McLachlan, Andrew J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291243/
https://ncbi.nlm.nih.gov/pubmed/17961191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.03040.x
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