Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2

The hedgehog (Hh) signaling pathway regulates the development of many organs in mammals, and activation of this pathway is widely observed in human cancers. Although it is known that Hh signaling activates the expression of genes involved in cell growth, the precise role of the Hh pathway in cancer...

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Detaylı Bibliyografya
Asıl Yazarlar: Abe, Yoshinori, Oda-Sato, Eri, Tobiume, Kei, Kawauchi, Keiko, Taya, Yoichi, Okamoto, Koji, Oren, Moshe, Tanaka, Nobuyuki
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2008
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290789/
https://ncbi.nlm.nih.gov/pubmed/18359851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712216105
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