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Loss of p53 enhances catalytic activity of IKKβ through O-linked β-N-acetyl glucosamine modification
The IκB kinase (IKK)-NF-κB pathway plays a critical role in oncogenesis. Recently, we have shown that p53 regulates glucose metabolism through the IKK-NF-κB pathway and that, in the absence of p53, the positive feedback loop between IKK-NF-κB and glycolysis has an integral role in oncogene-induced c...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2651314/ https://ncbi.nlm.nih.gov/pubmed/19202066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813210106 |
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