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Loss of p53 enhances catalytic activity of IKKβ through O-linked β-N-acetyl glucosamine modification

The IκB kinase (IKK)-NF-κB pathway plays a critical role in oncogenesis. Recently, we have shown that p53 regulates glucose metabolism through the IKK-NF-κB pathway and that, in the absence of p53, the positive feedback loop between IKK-NF-κB and glycolysis has an integral role in oncogene-induced c...

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Autori principali: Kawauchi, Keiko, Araki, Keigo, Tobiume, Kei, Tanaka, Nobuyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651314/
https://ncbi.nlm.nih.gov/pubmed/19202066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813210106
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