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Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2
The hedgehog (Hh) signaling pathway regulates the development of many organs in mammals, and activation of this pathway is widely observed in human cancers. Although it is known that Hh signaling activates the expression of genes involved in cell growth, the precise role of the Hh pathway in cancer...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2290789/ https://ncbi.nlm.nih.gov/pubmed/18359851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712216105 |
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