Molecular mechanism of a COOH-terminal gating determinant in the ROMK channel revealed by a Bartter's disease mutation

The ROMK subtypes of inward-rectifier K(+) channels mediate potassium secretion and regulate NaCl reabsorption in the kidney. Loss-of-function mutations in this pH-sensitive K(+) channel cause Bartter's disease, a familial salt wasting nephropathy. One disease-causing mutation truncates the ext...

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Hlavní autoři: Flagg, Thomas P, Yoo, Dana, Sciortino, Christopher M, Tate, Margaret, Romero, Michael F, Welling, Paul A
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2002
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290610/
https://ncbi.nlm.nih.gov/pubmed/12381810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2002.027581
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