Long-term expression of murine activated factor VII is safe, but elevated levels cause premature mortality

Intravenous infusion of recombinant human activated Factor VII (FVIIa) has been used for over a decade in the successful management of bleeding episodes in patients with inhibitory antibodies to Factor VIII or Factor IX. Previously, we showed that expression of murine FVIIa (mFVIIa) from an adeno-as...

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Detalhes bibliográficos
Main Authors: Aljamali, Majed N., Margaritis, Paris, Schlachterman, Alexander, Tai, Shing Jen, Roy, Elise, Bunte, Ralph, Camire, Rodney M., High, Katherine A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2289790/
https://ncbi.nlm.nih.gov/pubmed/18398505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32878
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