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Structural alteration of cofactor specificity in Corynebacterium 2,5-diketo-D-gluconic acid reductase

Corynebacterium 2,5-Diketo-D-gluconic acid reductase (2,5-DKGR) catalyzes the reduction of 2,5-diketo-D-gluconic acid (2,5-DKG) to 2-Keto-L-gulonic acid (2-KLG). 2-KLG is an immediate precursor to L-ascorbic acid (vitamin C), and 2,5-DKGR is, therefore, an important enzyme in a novel industrial meth...

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Detalhes bibliográficos
Main Authors: Sanli, Gulsah, Banta, Scott, Anderson, Stephen, Blaber, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2286697/
https://ncbi.nlm.nih.gov/pubmed/14718658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.03450704
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