Biochemical and Genetic Characterizations of a Novel Human Immunodeficiency Virus Type 1 Inhibitor That Blocks gp120-CD4 Interactions

BMS-378806 is a recently discovered small-molecule human immunodeficiency virus type 1 (HIV-1) attachment inhibitor with good antiviral activity and pharmacokinetic properties. Here, we demonstrate that the compound targets viral entry by inhibiting the binding of the HIV-1 envelope gp120 protein to...

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Hlavní autoři: Guo, Qi, Ho, Hsu-Tso, Dicker, Ira, Fan, Li, Zhou, Nannan, Friborg, Jacques, Wang, Tao, McAuliffe, Brian V., Wang, Hwei-gene Heidi, Rose, Ronald E., Fang, Hua, Scarnati, Helen T., Langley, David R., Meanwell, Nicholas A., Abraham, Ralph, Colonno, Richard J., Lin, Pin-fang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2003
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC228513/
https://ncbi.nlm.nih.gov/pubmed/12970437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.19.10528-10536.2003
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