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Significance in Replication of the Terminal Nucleotides of the Flavivirus Genome

Point mutations that resulted in a substitution of the conserved 3′-penultimate cytidine in genomic RNA or the RNA negative strand of the self-amplifying replicon of the Flavivirus Kunjin virus completely blocked in vivo replication. Similarly, substitutions of the conserved 3′-terminal uridine in t...

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Udgivet i:J Virol
Principais autores: Khromykh, Alexander A, Kondratieva, Natasha, Sgro, Jean-Yves, Palmenberg, Ann, Westaway, Edwin G
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2003
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC228497/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12970446/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.19.10623-10629.2003
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