Efficient trans-Complementation of the Flavivirus Kunjin NS5 Protein but Not of the NS1 Protein Requires Its Coexpression with Other Components of the Viral Replicase

Successful trans-complementation of the defective Kunjin virus (KUN) RNA FLdGDD with a deletion of the RNA polymerase motif GDD in the NS5 gene by using a BHK cell line, repBHK, that continuously produced a functionally active KUN replication complex (RC) from replicon RNA was recently reported (A....

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Bibliographic Details
Main Authors: Khromykh, Alexander A., Sedlak, Petra L., Guyatt, Kimberley J., Hall, Roy A., Westaway, Edwin G.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC113081/
https://ncbi.nlm.nih.gov/pubmed/10559344
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