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Complementation Analysis of the Flavivirus Kunjin NS3 and NS5 Proteins Defines the Minimal Regions Essential for Formation of a Replication Complex and Shows a Requirement of NS3 in cis for Virus Assembly

We have previously reported successful trans-complementation of defective Kunjin virus genomic RNAs with a range of large lethal deletions in the nonstructural genes NS1, NS3, and NS5 (A. A. Khromykh et al., J. Virol. 74:3253-3263, 2000). In this study we have mapped further the minimal region in th...

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Udgivet i:J Virol
Principais autores: Liu, Wen Jun, Sedlak, Petra L., Kondratieva, Natasha, Khromykh, Alexander A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2002
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136631/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12368319/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.21.10766-10775.2002
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