Complementation Analysis of the Flavivirus Kunjin NS3 and NS5 Proteins Defines the Minimal Regions Essential for Formation of a Replication Complex and Shows a Requirement of NS3 in cis for Virus Assembly

We have previously reported successful trans-complementation of defective Kunjin virus genomic RNAs with a range of large lethal deletions in the nonstructural genes NS1, NS3, and NS5 (A. A. Khromykh et al., J. Virol. 74:3253-3263, 2000). In this study we have mapped further the minimal region in th...

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Päätekijät: Liu, Wen Jun, Sedlak, Petra L., Kondratieva, Natasha, Khromykh, Alexander A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2002
Aiheet:
Replication
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC136631/
https://ncbi.nlm.nih.gov/pubmed/12368319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.21.10766-10775.2002
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