Significance in Replication of the Terminal Nucleotides of the Flavivirus Genome

Point mutations that resulted in a substitution of the conserved 3′-penultimate cytidine in genomic RNA or the RNA negative strand of the self-amplifying replicon of the Flavivirus Kunjin virus completely blocked in vivo replication. Similarly, substitutions of the conserved 3′-terminal uridine in t...

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Detalhes bibliográficos
Main Authors: Khromykh, Alexander A, Kondratieva, Natasha, Sgro, Jean-Yves, Palmenberg, Ann, Westaway, Edwin G
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC228497/
https://ncbi.nlm.nih.gov/pubmed/12970446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.19.10623-10629.2003
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