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The origin of FOXP3-expressing CD4(+) regulatory T cells: thymus or periphery

Naturally arising CD4(+) regulatory T cells, which engage in the maintenance of immunologic self-tolerance, specifically express FOXP3, which encodes a transcription-repressor protein. Genetic defects in FOXP3 cause IPEX, an X-linked autoimmune/inflammatory syndrome. With FOXP3 as a specific marker...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile nagusia: Sakaguchi, Shimon
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2003
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC228490/
https://ncbi.nlm.nih.gov/pubmed/14597756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200320274
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