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The origin of FOXP3-expressing CD4(+) regulatory T cells: thymus or periphery
Naturally arising CD4(+) regulatory T cells, which engage in the maintenance of immunologic self-tolerance, specifically express FOXP3, which encodes a transcription-repressor protein. Genetic defects in FOXP3 cause IPEX, an X-linked autoimmune/inflammatory syndrome. With FOXP3 as a specific marker...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2003
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC228490/ https://ncbi.nlm.nih.gov/pubmed/14597756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200320274 |
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