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Orientation-dependent and sequence-specific expansions of CTG/CAG trinucleotide repeats in Saccharomyces cerevisiae

A quantitative and selective genetic assay was developed to monitor expansions of trinucleotide repeats (TNRs) in yeast. A promoter containing 25 repeats allows expression of a URA3 reporter gene and yields sensitivity to the drug 5-fluoroorotic acid. Expansion of the TNR to 30 or more repeats turns...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Miret, Juan José, Pessoa-Brandão, Luis, Lahue, Robert S.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22849/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9770504/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.21.12438
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