Mitochondrial DNA mutations in human colonic crypt stem cells

The mitochondrial genome encodes 13 essential subunits of the respiratory chain and has remarkable genetics based on uniparental inheritance. Within human populations, the mitochondrial genome has a high rate of sequence divergence with multiple polymorphic variants and thus has played a major role...

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Autori principali: Taylor, Robert W., Barron, Martin J., Borthwick, Gillian M., Gospel, Amy, Chinnery, Patrick F., Samuels, David C., Taylor, Geoffrey A., Plusa, Stefan M., Needham, Stephanie J., Greaves, Laura C., Kirkwood, Thomas B.L., Turnbull, Douglass M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2003
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC228466/
https://ncbi.nlm.nih.gov/pubmed/14597761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200319435
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