NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis

Angiotensin II (Ang II) is a pro-oxidant and fibrogenic cytokine. We investigated the role of NADPH oxidase in Ang II–induced effects in hepatic stellate cells (HSCs), a fibrogenic cell type. Human HSCs express mRNAs of key components of nonphagocytic NADPH oxidase. Ang II phosphorylated p47(phox),...

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Hauptverfasser: Bataller, Ramón, Schwabe, Robert F., Choi, Youkyung H., Yang, Liu, Paik, Yong Han, Lindquist, Jeffrey, Qian, Ting, Schoonhoven, Robert, Hagedorn, Curt H., Lemasters, John J., Brenner, David A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2003
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC228420/
https://ncbi.nlm.nih.gov/pubmed/14597764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200318212
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