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Activation of microhelix charging by localized helix destabilization

We report that aminoacylation of minimal RNA helical substrates is enhanced by mismatched or unpaired nucleotides at the first position in the helix. Previously, we demonstrated that the class I methionyl-tRNA synthetase aminoacylates RNA microhelices based on the acceptor stem of initiator and elon...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Alexander, Rebecca W., Nordin, Brian E., Schimmel, Paul
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22811/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9770466/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.21.12214
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