DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes

Silencing of transposable elements occurs during fetal gametogenesis in males via de novo DNA methylation of their regulatory regions. The loss of MILI (miwi-like) and MIWI2 (mouse piwi 2), two mouse homologs of Drosophila Piwi, activates retrotransposon gene expression by impairing DNA methylation...

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Detalhes bibliográficos
Main Authors: Kuramochi-Miyagawa, Satomi, Watanabe, Toshiaki, Gotoh, Kengo, Totoki, Yasushi, Toyoda, Atsushi, Ikawa, Masahito, Asada, Noriko, Kojima, Kanako, Yamaguchi, Yuka, Ijiri, Takashi W., Hata, Kenichiro, Li, En, Matsuda, Yoichi, Kimura, Tohru, Okabe, Masaru, Sakaki, Yoshiyuki, Sasaki, Hiroyuki, Nakano, Toru
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279202/
https://ncbi.nlm.nih.gov/pubmed/18381894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1640708
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