FOXP3(+ )T(regs )and B7-H1(+)/PD-1(+ )T lymphocytes co-infiltrate the tumor tissues of high-risk breast cancer patients: Implication for immunotherapy

BACKGROUND: Recent studies have demonstrated a direct involvement of B7-H1, PD-1 and FOXP3 molecules in the immune escape of cancer. B7-H1 is an inhibitory molecule that binds to PD-1 on T lymphocytes, while FOXP3 is a marker for regulatory T cells (T(regs)). We have previously demonstrated the asso...

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Hauptverfasser: Ghebeh, Hazem, Barhoush, Eman, Tulbah, Asma, Elkum, Naser, Al-Tweigeri, Taher, Dermime, Said
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2008
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279136/
https://ncbi.nlm.nih.gov/pubmed/18294387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-57
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