K(+)-dependent gating of K(ir)1.1 channels is linked to pH gating through a conformational change in the pore

1. We have used giant patch-clamp recording to investigate the interaction between pH gating and K(+)-dependent gating in rat K(ir)1.1 (ROMK) channels heterologously expressed in Xenopus oocytes. 2. Gating by intracellular protons (pH gating) and extracellular K(+) ions (K(+)-dependent gating) is a...

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Detalhes bibliográficos
Main Authors: Schulte, Uwe, Weidemann, Susanne, Ludwig, Jost, Ruppersberg, Johann Peter, Fakler, Bernd
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2001
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278684/
https://ncbi.nlm.nih.gov/pubmed/11432991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2001.t01-1-00049.x
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