Functional consequences of the arrhythmogenic G306R KvLQT1 K(+) channel mutant probed by viral gene transfer in cardiomyocytes

1. I(Ks), the slow component of the delayed rectifier potassium current, figures prominently in the repolarization of heart cells. The K(+) channel gene KvLQT1 is mutated in the heritable long QT (LQT) syndrome. Heterologous coexpression of KvLQT1 and the accessory protein minK yields an I(Ks)-like...

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Bibliographic Details
Main Authors: Li, Ronald A, Miake, Junichiro, Hoppe, Uta C, Johns, David C, Marbán, Eduardo, Nuss, H Bradley
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2001
Subjects:
Rapid Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278611/
https://ncbi.nlm.nih.gov/pubmed/11351021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2001.0127b.x
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