A dual CT-MR dendrimer contrast agent as a surrogate marker for convection-enhanced delivery of intracerebral macromolecular therapeutic agents

The feasibility of using Gd dendrimer-based macromolecules (Gd-G8 dendrimer) as a dual CT and MR contrast agent for monitoring convection-enhanced delivery (CED) of therapy in the brain is evaluated both in vitro and in vivo with optimal dosing established. In vitro CT attenuation values of the Gd-b...

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Detalhes bibliográficos
Main Authors: Regino, Celeste Aida S., Walbridge, Stuart, Bernardo, Marcelino, Wong, Karen J., Johnson, Dennis, Lonser, Russell, Oldfield, Edward H., Choyke, Peter L., Brechbiel, Martin W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278235/
https://ncbi.nlm.nih.gov/pubmed/18335478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmmi.223
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