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A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes
Nifurtimox and benznidazole are the front-line drugs used to treat Chagas disease, the most important parasitic infection in the Americas. These agents function as prodrugs and must be activated within the parasite to have trypanocidal effects. Despite >40 years of research, the mechanism(s) of a...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2278226/ https://ncbi.nlm.nih.gov/pubmed/18367671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711014105 |
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