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A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5

The yeast ABC transporter Pdr5 plays a major role in drug resistance against a large number of structurally unrelated compounds. Although Pdr5 has been extensively studied, many important aspects regarding its molecular mechanisms remain unresolved. For example, a striking degeneration of conserved...

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Detalhes bibliográficos
Main Authors: Ernst, Robert, Kueppers, Petra, Klein, Cornelia M., Schwarzmueller, Tobias, Kuchler, Karl, Schmitt, Lutz
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278221/
https://ncbi.nlm.nih.gov/pubmed/18356296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800191105
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