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Activation of protein kinase C modulates BACE1-mediated β-secretase activity
β-site APP cleavage enzyme 1 (BACE1) is the β-secretase responsible for generating amyloid-β (Aβ) peptides in Alzheimer’s disease (AD). Previous studies suggest that activation of protein kinase C (PKC) modulates the β-secretase-mediated cleavage of APP and reduces the production of Aβ. The mechanis...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2278113/ https://ncbi.nlm.nih.gov/pubmed/17157415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2006.11.001 |
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