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RNA aptamers selectively modulate protein recruitment to the cytoplasmic domain of β-secretase BACE1 in vitro

The β-amyloid peptide (Aβ) is a major component of the Alzheimer's disease (AD)-associated senile plaques and is generated by sequential cleavage of the β-amyloid precursor protein (APP) by β-secretase and γ-secretase. Since BACE1 initiates Aβ generation it represents a valuable target to inter...

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Detalhes bibliográficos
Main Authors: Rentmeister, Andrea, Bill, Anke, Wahle, Tina, Walter, Jochen, Famulok, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1557694/
https://ncbi.nlm.nih.gov/pubmed/16888322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.126306
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