The cAMP binding protein Epac modulates Ca(2+) sparks by a Ca(2+)/calmodulin kinase signalling pathway in rat cardiac myocytes

cAMP is a powerful second messenger whose known general effector is protein kinase A (PKA). The identification of a cAMP binding protein, Epac, raises the question of its role in Ca(2+) signalling in cardiac myocytes. In this study, we analysed the effects of Epac activation on Ca(2+) handling by us...

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Autors principals: Pereira, Laetitia, Métrich, Mélanie, Fernández-Velasco, María, Lucas, Alexandre, Leroy, Jérôme, Perrier, Romain, Morel, Eric, Fischmeister, Rodolphe, Richard, Sylvain, Bénitah, Jean-Pierre, Lezoualc'h, Frank, Gómez, Ana María
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2007
Matèries:
Cardiovascular
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2277038/
https://ncbi.nlm.nih.gov/pubmed/17599964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.133066
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