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Induction of Active Tolerance and Involvement of CD1d-Restricted Natural Killer T Cells in Anti-CD3 F(ab′)(2) Treatment-Reversed New-Onset Diabetes in Nonobese Diabetic Mice
The application of anti-CD3 F(ab′)(2) monoclonal antibodies has recently been expanded to treat established autoimmune diseases, including type 1 diabetes. However, the mechanism underlying their effect remains largely unclear. We report that short-phase administration of anti-CD3 F(ab′)(2) antibodi...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Investigative Pathology
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2276429/ https://ncbi.nlm.nih.gov/pubmed/18349126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070159 |
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