Age-Related Changes in Bone Morphology Are Accelerated in Group VIA Phospholipase A(2) (iPLA(2)β)-Null Mice

Phospholipases A(2) (PLA(2)) hydrolyze the sn−2 fatty acid substituent, such as arachidonic acid, from phospholipids, and arachidonate metabolites are recognized mediators of bone modeling. We have previously generated knockout (KO) mice lacking the group VIA PLA(2) (iPLA(2)β), which participates in...

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Autors principals: Ramanadham, Sasanka, Yarasheski, Kevin E., Silva, Matthew J., Wohltmann, Mary, Novack, Deborah Veis, Christiansen, Blaine, Tu, Xiaolin, Zhang, Sheng, Lei, Xiaoyong, Turk, John
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2008
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276416/
https://ncbi.nlm.nih.gov/pubmed/18349124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070756
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