Age-Related Changes in Bone Morphology Are Accelerated in Group VIA Phospholipase A(2) (iPLA(2)β)-Null Mice

Phospholipases A(2) (PLA(2)) hydrolyze the sn−2 fatty acid substituent, such as arachidonic acid, from phospholipids, and arachidonate metabolites are recognized mediators of bone modeling. We have previously generated knockout (KO) mice lacking the group VIA PLA(2) (iPLA(2)β), which participates in...

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Autori principali: Ramanadham, Sasanka, Yarasheski, Kevin E., Silva, Matthew J., Wohltmann, Mary, Novack, Deborah Veis, Christiansen, Blaine, Tu, Xiaolin, Zhang, Sheng, Lei, Xiaoyong, Turk, John
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2008
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Regular Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276416/
https://ncbi.nlm.nih.gov/pubmed/18349124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070756
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