Age-Related Changes in Bone Morphology Are Accelerated in Group VIA Phospholipase A(2) (iPLA(2)β)-Null Mice

Phospholipases A(2) (PLA(2)) hydrolyze the sn−2 fatty acid substituent, such as arachidonic acid, from phospholipids, and arachidonate metabolites are recognized mediators of bone modeling. We have previously generated knockout (KO) mice lacking the group VIA PLA(2) (iPLA(2)β), which participates in...

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Hlavní autoři: Ramanadham, Sasanka, Yarasheski, Kevin E., Silva, Matthew J., Wohltmann, Mary, Novack, Deborah Veis, Christiansen, Blaine, Tu, Xiaolin, Zhang, Sheng, Lei, Xiaoyong, Turk, John
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2008
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276416/
https://ncbi.nlm.nih.gov/pubmed/18349124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070756
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