Age-Related Changes in Bone Morphology Are Accelerated in Group VIA Phospholipase A(2) (iPLA(2)β)-Null Mice

Phospholipases A(2) (PLA(2)) hydrolyze the sn−2 fatty acid substituent, such as arachidonic acid, from phospholipids, and arachidonate metabolites are recognized mediators of bone modeling. We have previously generated knockout (KO) mice lacking the group VIA PLA(2) (iPLA(2)β), which participates in...

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Detalhes bibliográficos
Main Authors: Ramanadham, Sasanka, Yarasheski, Kevin E., Silva, Matthew J., Wohltmann, Mary, Novack, Deborah Veis, Christiansen, Blaine, Tu, Xiaolin, Zhang, Sheng, Lei, Xiaoyong, Turk, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276416/
https://ncbi.nlm.nih.gov/pubmed/18349124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070756
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