Age-Related Changes in Bone Morphology Are Accelerated in Group VIA Phospholipase A(2) (iPLA(2)β)-Null Mice

Phospholipases A(2) (PLA(2)) hydrolyze the sn−2 fatty acid substituent, such as arachidonic acid, from phospholipids, and arachidonate metabolites are recognized mediators of bone modeling. We have previously generated knockout (KO) mice lacking the group VIA PLA(2) (iPLA(2)β), which participates in...

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Détails bibliographiques
Auteurs principaux: Ramanadham, Sasanka, Yarasheski, Kevin E., Silva, Matthew J., Wohltmann, Mary, Novack, Deborah Veis, Christiansen, Blaine, Tu, Xiaolin, Zhang, Sheng, Lei, Xiaoyong, Turk, John
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2008
Sujets:
Regular Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276416/
https://ncbi.nlm.nih.gov/pubmed/18349124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070756
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