Inhibition of CCN6 (Wnt-1-Induced Signaling Protein 3) Down-Regulates E-Cadherin in the Breast Epithelium through Induction of Snail and ZEB1

The cysteine-rich protein CCN6 [or Wnt-1-induced signaling protein 3 (WISP3)] exerts tumor-suppressive effects in aggressive inflammatory breast cancer. Loss of CCN6 is associated with poorly differentiated phenotypes and increased invasion. Here, we show that reduction of CCN6 expression occurs in...

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Detalhes bibliográficos
Main Authors: Huang, Wei, Zhang, Yanhong, Varambally, Sooryanarayana, Chinnaiyan, Arul M., Banerjee, Mousumi, Merajver, Sofia D., Kleer, Celina G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276413/
https://ncbi.nlm.nih.gov/pubmed/18321996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070899
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