An antiproliferative BMP-2/PPARγ/apoE axis in human and murine SMCs and its role in pulmonary hypertension

Loss-of-function mutations in bone morphogenetic protein receptor II (BMP-RII) are linked to pulmonary arterial hypertension (PAH); the ligand for BMP-RII, BMP-2, is a negative regulator of SMC growth. Here, we report an interplay between PPARγ and its transcriptional target apoE downstream of BMP-2...

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Autors principals: Hansmann, Georg, de Jesus Perez, Vinicio A., Alastalo, Tero-Pekka, Alvira, Cristina M., Guignabert, Christophe, Bekker, Janine M., Schellong, Stefan, Urashima, Takashi, Wang, Lingli, Morrell, Nicholas W., Rabinovitch, Marlene
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2008
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276393/
https://ncbi.nlm.nih.gov/pubmed/18382765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32503
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