Detergent-insoluble Aggregates Associated with Amyotrophic Lateral Sclerosis in Transgenic Mice Contain Primarily Full-length, Unmodified Superoxide Dismutase-1

Determining the composition of aggregated superoxide dismutase 1 (SOD1) species associated with amyotrophic lateral sclerosis (ALS), especially with respect to co-aggregated proteins and post-translational modifications, could identify cellular or biochemical factors involved in the formation of the...

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Main Authors: Shaw, Bryan F., Lelie, Herman L., Durazo, Armando, Nersissian, Aram M., Xu, Guillan, Chan, Pik K., Gralla, Edith B., Tiwari, Ashutosh, Hayward, Lawrence J., Borchelt, David R., Valentine, Joan S., Whitelegge, Julian P.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2008
Teme:
Enzyme Catalysis and Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276386/
https://ncbi.nlm.nih.gov/pubmed/18192269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707751200
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