cAMP-dependent Protein Kinase Phosphorylation Produces Interdomain Movement in SUR2B Leading to Activation of the Vascular K(ATP) Channel

Vascular ATP-sensitive K(+) channels are activated by multiple vasodilating hormones and neurotransmitters via PKA. A critical PKA phosphorylation site (Ser-1387) is found in the second nucleotide-binding domain (NBD(2)) of the SUR2B subunit. To understand how phosphorylation at Ser-1387 leads to ch...

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Bibliographic Details
Main Authors: Shi, Yun, Chen, Xianfeng, Wu, Zhongying, Shi, Weiwei, Yang, Yang, Cui, Ningren, Jiang, Chun, Harrison, Robert W.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Membrane Transport, Structure, Function, and Biogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276326/
https://ncbi.nlm.nih.gov/pubmed/18198173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709941200
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