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TOLL-LIKE RECEPTORS STIMULATE REGULATED INTRAMEMBRANE PROTEOLYSIS OF THE CSF-1 RECEPTOR THROUGH ERK ACTIVATION

The CSF-1 receptor is a protein-tyrosine kinase that regulates the renewal, differentiation and activation of monocytes and macrophages. We have recently shown that the CSF-1 receptor undergoes regulated intramembrane proteolysis, or RIPping. Here, we report that RIPping can be observed in response...

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Main Authors: Glenn, Gary, van der Geer, Peter
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276177/
https://ncbi.nlm.nih.gov/pubmed/18294963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2008.02.029
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