G-CSF regulates hematopoietic stem cell activity, in part, through activation of toll-like receptor signaling

Recent studies demonstrate that inflammatory signals regulate hematopoietic stem cells (HSCs). Granulocyte-colony stimulating factor (G-CSF) is often induced with infection and plays a key role in the stress granulopoiesis response. However, its effects on HSCs are less clear. Herein, we show that t...

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Main Authors: Schuettpelz, Laura G., Borgerding, Joshua N., Christopher, Matthew J, Gopalan, Priya K., Romine, Molly P., Herman, Angela C., Woloszynek, Jill R., Greenbaum, Adam M., Link, Daniel C.
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130805/
https://ncbi.nlm.nih.gov/pubmed/24518205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.68
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