Precision and linearity targets for validation of an IFNγ ELISPOT, cytokine flow cytometry, and tetramer assay using CMV peptides

BACKGROUND: Single-cell assays of immune function are increasingly used to monitor T cell responses in immunotherapy clinical trials. Standardization and validation of such assays are therefore important to interpretation of the clinical trial data. Here we assess the levels of intra-assay, inter-as...

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Detalhes bibliográficos
Main Authors: Maecker, Holden T, Hassler, Jeffrey, Payne, Janice K, Summers, Amanda, Comatas, Karrie, Ghanayem, Manar, Morse, Michael A, Clay, Timothy M, Lyerly, Herbert K, Bhatia, Sonny, Ghanekar, Smita A, Maino, Vernon C, delaRosa, Corazon, Disis, Mary L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Methodology Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275721/
https://ncbi.nlm.nih.gov/pubmed/18366814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-9-9
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