Crystallographic Study of Hydration of an Internal Cavity in Engineered Proteins with Buried Polar or Ionizable Groups

Although internal water molecules are essential for the structure and function of many proteins, the structural and physical factors that govern internal hydration are poorly understood. We have examined the molecular determinants of internal hydration systematically, by solving the crystal structur...

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Bibliographic Details
Main Authors: Schlessman, Jamie L., Abe, Colby, Gittis, Apostolos, Karp, Daniel A., Dolan, Michael A., García-Moreno E., Bertrand
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2008
Subjects:
Proteins
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275713/
https://ncbi.nlm.nih.gov/pubmed/18178652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.122473
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