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Dihydrofolate reductase gene expression in cultured mouse cells is regulated by transcript stabilization in the nucleus

Methotrexate-resistant cells, which contain a 500-fold amplification of dihydrofolate reductase (DHFR) genes, were used as a model system for studying the regulation of DHFR gene expression during growth stimulation. We have shown that a threefold increase in DHFR mRNA levels following growth stimul...

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Detalhes bibliográficos
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1984
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275613/
https://ncbi.nlm.nih.gov/pubmed/6736126
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