The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro

Despite a high initial response rate to first-line platinum/paclitaxel chemotherapy, most women with epithelial ovarian cancer relapse with recurrent disease that becomes refractory to further cytotoxic treatment. We have previously shown that the E3 ubiquitin ligase, EDD, a regulator of DNA damage...

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Detalhes bibliográficos
Main Authors: O'Brien, P M, Davies, M J, Scurry, J P, Smith, A N, Barton, C A, Henderson, M J, Saunders, D N, Gloss, B S, Patterson, K I, Clancy, J L, Heinzelmann-Schwarz, V A, Scolyer, R A, Zeng, Y, Williams, E D, Scurr, L, DeFazio, A, Quinn, D I, Watts, C K W, Hacker, N F, Henshall, S M, Sutherland, R L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275489/
https://ncbi.nlm.nih.gov/pubmed/18349819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604281
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