Multiple molecular dynamics simulation of the isoforms of human translation elongation factor 1A reveals reversible fluctuations between "open" and "closed" conformations and suggests specific for eEF1A1 affinity for Ca(2+)-calmodulin

BACKGROUND: Eukaryotic translation elongation factor eEF1A directs the correct aminoacyl-tRNA to ribosomal A-site. In addition, eEF1A is involved in carcinogenesis and apoptosis and can interact with large number of non-translational ligands. There are two isoforms of eEF1A, which are 98% similar. D...

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Bibliografski detalji
Glavni autori: Kanibolotsky, Dmitry S, Novosyl'na, Oleksandra V, Abbott, Catherine M, Negrutskii, Boris S, El'skaya, Anna V
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2008
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275276/
https://ncbi.nlm.nih.gov/pubmed/18221514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-8-4
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