Mammalian translation elongation factor eEF1A2: X-ray structure and new features of GDP/GTP exchange mechanism in higher eukaryotes

Eukaryotic elongation factor eEF1A transits between the GTP- and GDP-bound conformations during the ribosomal polypeptide chain elongation. eEF1A*GTP establishes a complex with the aminoacyl-tRNA in the A site of the 80S ribosome. Correct codon–anticodon recognition triggers GTP hydrolysis, with sub...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Crepin, Thibaut, Shalak, Vyacheslav F., Yaremchuk, Anna D., Vlasenko, Dmytro O., McCarthy, Andrew, Negrutskii, Boris S., Tukalo, Michail A., El'skaya, Anna V.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227793/
https://ncbi.nlm.nih.gov/pubmed/25326326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku974
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