Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage

The human AP-endonuclease (APE1/Ref-1), an essential multifunctional protein, plays a central role in the repair of oxidative base damage via the DNA base excision repair (BER) pathway. The mammalian AP-endonuclease (APE1) overexpression is often observed in tumor cells, and confers resistance to va...

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Main Authors: Zaky, Amira, Busso, Carlos, Izumi, Tadahide, Chattopadhyay, Ranajoy, Bassiouny, Ahmad, Mitra, Sankar, Bhakat, Kishor K.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2008
Assuntos:
Molecular Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275136/
https://ncbi.nlm.nih.gov/pubmed/18208837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm1173
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