A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

We tested 310,605 single-nucleotide polymorphisms for association in 778 celiac disease cases and 1422 controls. Outside the HLA, the most significant finding (rs13119723, P=2.0 × 10(−7), empirical genome-wide significance P=0.045) was in the KIAA1109/Tenr/IL2/IL21 linkage disequilibrium block. Asso...

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Autori principali: van Heel, David A, Franke, Lude, Hunt, Karen A, Gwilliam, Rhian, Zhernakova, Alexandra, Inouye, Mike, Wapenaar, Martin C, Barnardo, Martin CNM, Bethel, Graeme, Holmes, Geoffrey KT, Feighery, Con, Jewell, Derek, Kelleher, Dermot, Kumar, Parveen, Travis, Simon, Walters, Julian RF, Sanders, David S, Howdle, Peter, Swift, Jill, Playford, Raymond J, McLaren, William M, Mearin, M Luisa, Mulder, Chris J, McManus, Ross, McGinnis, Ralph, Cardon, Lon R, Deloukas, Panos, Wijmenga, Cisca
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2274985/
https://ncbi.nlm.nih.gov/pubmed/17558408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng2058
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