Acrolein-Activated Matrix Metalloproteinase 9 Contributes to Persistent Mucin Production

Chronic obstructive pulmonary disease (COPD), a global public health problem, is characterized by progressive difficulty in breathing, with increased mucin production, especially in the small airways. Acrolein, a constituent of cigarette smoke and an endogenous mediator of oxidative stress, increase...

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Autori principali: Deshmukh, Hitesh S., Shaver, Colleen, Case, Lisa M., Dietsch, Maggie, Wesselkamper, Scott C., Hardie, William D., Korfhagen, Thomas R., Corradi, Massimo, Nadel, Jay A., Borchers, Michael T., Leikauf, George D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2274947/
https://ncbi.nlm.nih.gov/pubmed/18006877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2006-0339OC
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