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Boosting with recombinant vaccinia increases immunogenicity and protective efficacy of malaria DNA vaccine

To enhance the efficacy of DNA malaria vaccines, we evaluated the effect on protection of immunizing with various combinations of DNA, recombinant vaccinia virus, and a synthetic peptide. Immunization of BALB/c mice with a plasmid expressing Plasmodium yoelii (Py) circumsporozoite protein (CSP) indu...

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Autors principals: Sedegah, Martha, Jones, Trevor R., Kaur, Manjit, Hedstrom, Richard, Hobart, Peter, Tine, John A., Hoffman, Stephen L.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC22711/
https://ncbi.nlm.nih.gov/pubmed/9636204
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